Niacinamide

INCI: Niacinamide (Vitamin B3)

Active Ingredient

The Balancer

A small mound of fine white crystalline powder on a smooth, light-colored surface.

Harness the “Great Communicator” power of Vitamin B3 to normalise oil production and rebuild a compromised lipid barrier. By acting as a cellular director and a tone equaliser, it transforms chaotic, uneven complexions into a state of calm, resilient clarity.

What it is

Niacinamide is the “Cellular Director”, synthetically derived to ensure absolute purity and stability, completely free from the impurities sometimes found in plant-extracted equivalents.

A close-up of a clear dropper releasing a droplet of liquid onto a smooth white surface, with a niacinamide chemical structure diagram shown to the right.

Why it works

The power of Niacinamide lies in its ability to communicate directly with skin cells. Research indicates that Niacinamide signals the skin to synthesise more ceramides and free fatty acids – the vital “mortar” holding your skin cells together. While other ingredients might temporarily coat the skin, Niacinamide actively trains it to function better on its own.

How it works

  1. Ceramide Synthesis:

    The Science: Niacinamide upregulates the production of epidermal ceramides and other stratum corneum lipids, effectively repairing compromised barrier function.

    The Translation: Think of it as the “Barrier Builder.” It tells your skin to produce its own natural protective oils, keeping irritants out and vital hydration securely locked in.

  2. Sebum Regulation:


    The Science:
    It limits the overproduction of sebum (oil) by sebaceous glands without dehydrating the surrounding epidermal tissue.

    The Translation: It acts as an “Oil Balancer.” Instead of violently stripping away excess oil and drying out your face, it simply asks your pores to stop overproducing it in the first place.

  3. Melanosome Transfer Inhibition:


    The Science:
    It significantly decreases hyperpigmentation by gently disrupting the transfer of melanosomes (pigment bundles) from melanocytes to the surrounding keratinocytes (skin cells).

    The Translation: It’s a “Tone Equaliser.” It doesn’t bleach the skin; it just politely intercepts the signals that cause dark spots and post-blemish marks to form on the surface.

Synergistic Interactions

Pairs with Ceramides: The “Fortification Team.” Niacinamide tells the skin to make more ceramides, while topical ceramides provide an immediate, soothing reinforcement to the outer layer.

Pairs with Zinc PCA: The “Clarifying Duo.” Niacinamide normalises oil production overall, while Zinc targets the specific bacteria that thrive in oily environments.

FAQs
Can I use Niacinamide and Vitamin C together?

Yes. The old myth that they cancel each other out or create a skin-reddening flush is based on outdated 1960s research that used highly unstable forms of both ingredients at extreme, unrealistic temperatures. In modern, premium artisan formulations, they are actually an excellent team for promoting a radiant complexion.

Will Niacinamide cause my skin to purge?

It shouldn’t. Niacinamide does not stimulate cellular turnover the way exfoliants (AHAs/BHAs) do, which is the biological mechanism behind a true “purge.” If you experience a sudden breakout from a new Niacinamide product, your skin is likely reacting to a concentration that is far too high, or to a heavy base ingredient.

Why did Niacinamide make my face flush red in the past?

You likely used a formula that had degraded, had a pH that was too acidic (causing it to convert to nicotinic acid), or you used a concentration well above the 5% clinical threshold.

Is it safe to use twice a day?

Absolutely. Providing the formulation is within the optimal, non-irritating 2-5% range, it is gentle enough to be a staple in both your morning and evening routine

Safety Profile

The CIR Expert Panel identifies Niacinamide as safe. It is one of the most widely tolerated actives in dermatology when formulated correctly, making it highly suitable for acne-prone, sensitive, and mature skin profiles.

SOURCES

ECHA (European Chemicals Agency): Niacinamide Substance Info (CAS 98-92-0)

PubChem (National Library of Medicine): Niacinamide Compound Summary

CIR (Cosmetic Ingredient Review): Final Report of the Safety Assessment of Niacinamide

Journal of Clinical and Aesthetic Dermatology: Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance

Handmade in Highfields QLD, Australia

© 2026 All Rights Reserved.

Welcome to Pattini Skincare

Schedule Appointment

Fill out the form below, and we will be in touch shortly.

CLIENT CONTACT & BASIC INFO
SKIN CONCERNS & GOALS
CURRENT ROUTINE & HISTORY
APPOINTMENT PREFERENCES
CONSENT & NOTES